Aspirin enteric-coated tablets

[Drug name] Common name: Aspirin enteric-coated tablets

【Ingredients】Aspirin

[Characteristics] This product is a white enteric-coated tablet, which appears white after the coating is removed.

【Function Indications】

Anti-platelet aggregation, can reduce the formation of thrombus. Reduce the risk of morbidity in patients with suspected acute myocardial infarction; prevent recurrence of myocardial infarction; secondary prevention of stroke; reduce the risk of transient ischemic attack (TIA) and subsequent stroke; reduce the morbidity of patients with stable and unstable angina pectoris Risks; after arterial surgery or interventional procedures, such as percutaneous transluminal coronary angioplasty (PTCA), coronary artery bypass surgery (CABG), carotid endarterectomy, arteriovenous shunt; prevention of deep veins after major surgery Thrombosis and pulmonary embolism; reduce the risk of myocardial infarction in those with cardiovascular risk factors (family history of coronary heart disease, diabetes, dyslipidemia, hypertension, obesity, smoking history, and those over 50 years old).

【Dosage】

Take orally. Enteric-coated tablets should be taken with appropriate amount of water before meals.

Reduce the risk of patients with suspected acute myocardial infarction: It is recommended that the first dose is 300mg, chew it before taking it for rapid absorption. From now on, 100-200mg per day.

Prevent recurrence of myocardial infarction: 100-300 mg daily.

Secondary prevention of stroke: 100-300 mg daily.

Reduce the risk of transient ischemic attack (TIA) and subsequent stroke: 100-300 mg daily.

Reduce the risk of angina in patients with stable and unstable angina: 100-300 mg daily.

After arterial surgery or interventional procedures, such as percutaneous transluminal coronary angioplasty (PTCA), coronary artery bypass surgery (CABG), carotid endarterectomy, and arteriovenous shunt surgery: 100-300 mg daily.

Prevention of deep vein thrombosis and pulmonary embolism after major surgery: 100-200 mg daily.

To reduce the risk of myocardial infarction for those with cardiovascular risk factors (family history of coronary heart disease, diabetes, dyslipidemia, hypertension, obesity, smoking history, and those over 50 years old): 100 mg per day.

【Adverse reactions】

Upper and lower gastrointestinal discomfort, such as indigestion, gastrointestinal and abdominal pain. Rare gastrointestinal inflammation, gastroduodenal ulcer. Very rarely, gastrointestinal bleeding and perforation may occur, along with laboratory abnormalities and clinical symptoms. Aspirin may increase the risk of bleeding due to its inhibitory effect on platelets. Observed bleeding includes intraoperative bleeding, hematoma, epistaxis, genitourinary bleeding, and gingival bleeding. There have also been reports of rare to extremely rare bleeding, such as gastrointestinal bleeding, cerebral hemorrhage (in hypertensive patients with poorly controlled blood pressure and/or in combination with anticoagulants), which may be life-threatening. Acute or chronic bleeding may result in anemia/iron deficiency anemia (eg, occult microbleeds), with laboratory abnormalities and clinical symptoms such as weakness, pallor, and hypotension. Hemolysis and hemolytic anemia occur in patients with severe glucose-6-phosphate dehydrogenase (G6PD) deficiency. Kidney injury and acute renal failure. Anaphylaxis is associated with corresponding laboratory abnormalities and clinical symptoms, including asthma symptoms and mild to moderate skin reactions. Respiratory, gastrointestinal, and cardiovascular systems, including rash, urticaria, edema, pruritus, cardiovascular-respiratory discomfort, and very rarely serious reactions including anaphylactic shock. Very rare transient liver damage with elevated liver aminotransferases. Dizziness and tinnitus in overdose.

【Taboo】

Allergy to aspirin or other salicylates, or any other ingredient of the medicine;

History of asthma caused by salicylates or salicylic acid-containing substances, NSAIDs;

Active peptic ulcer;

Bleeding constitution;

severe kidney failure;

severe liver failure;

severe heart failure;

Concomitant use with methotrexate (at a dose of 15 mg/week or more) (see Drug Interactions);

Last trimester of pregnancy.

【Precautions】

Allergy to analgesics, anti-inflammatory drugs, anti-rheumatic drugs, or other allergic reactions.

History of gastroduodenal ulcers, including chronic ulcers, recurrent ulcers, and gastrointestinal bleeding.

Use with anticoagulants (see Drug Interactions).

In patients with impaired renal function or cardiovascular circulation (e.g., renovascular disease, congestive heart failure, volume depletion, major surgery, sepsis, or severe hemorrhagic events), acetylsalicylic acid may further increase renal impairment and Risk of acute renal failure.

Acetylsalicylic acid may induce hemolytic anemia in patients with severe glucose-6-condensate dehydrogenase (G6PD) deficiency. Factors that can increase the risk of hemolysis include high doses, fever, and acute infection.

Liver damage;

Ibuprofen may interfere with the action of aspirin enteric-coated tablets. Patients should consult their doctor if they take aspirin and ibuprofen together.

Aspirin may cause bronchospasm and cause asthma attacks or other allergic reactions. Risk factors include bronchial asthma, hay fever, nasal polyps, or chronic respiratory infections. This also applies to patients with allergic reactions to other substances (e.g. skin reactions, itching, rash).

Because the inhibitory effect of aspirin on platelet aggregation can last for days, it may lead to increased bleeding during or after surgery.

Low-dose aspirin reduces the elimination of uric acid. Can induce gout.

【medicine interactions】

Disabled:

Methotrexate (dose 15 mg/week or more):

Increased hematological toxicity of methotrexate (salicylic acid and methotrexate compete for binding to plasma proteins, reducing renal clearance of methotrexate) (see Contraindications).

Caution should be exercised when using:

Methotrexate (dose less than 15 mg/week):

Increased hematological toxicity of methotrexate (salicylic acid and methotrexate compete with plasma proteins for binding and reduce renal clearance of methotrexate). (See Taboo)

Ibuprofen

Concomitant use of ibuprofen may interfere with the irreversible inhibitory effect of aspirin on platelets. The cardiovascular protective effect of aspirin may be limited when ibuprofen is used in patients at risk for cardiovascular disease (see Precautions).

Anticoagulants, such as coumarin derivatives, heparin:

Increased risk of bleeding.

High doses of other salicylate-containing NSAIDs:

Increased risk of ulceration and gastrointestinal bleeding due to synergistic effects.

Anti-gout drugs that promote uric acid excretion, such as probenecid and benzotrione:

Decreased uricosuric effect (competes for renal tubular elimination of uric acid).

Digoxin:

Increased plasma concentrations of digoxin due to decreased renal clearance.

Antidiabetic drugs, such as insulin, sulfonylureas:

High-dose aspirin has a hypoglycemic effect and enhances the hypoglycemic effect, and can compete with sulfonylureas for binding to plasma proteins.

Diuretics combined with high-dose aspirin:

Reduces renal prostaglandin synthesis and reduces glomerular filtration.

Glucocorticoids, except hydrocortisone for replacement treatment of Addison’s disease:

Blood concentrations of salicylic acid are reduced during corticosteroid therapy, and because corticosteroids increase the elimination of salicylic acid, the risk of salicylic acid overdose is increased after corticosteroid therapy is discontinued.

Angiotensin-converting enzyme inhibitors (ACE) combined with high-dose aspirin:

Decreased glomerular filtration by inhibition of prostaglandins. In addition, the antihypertensive effect is reduced.

Valproic acid:

Competes with plasma proteins for binding and increases the toxicity of valproic acid.

Ethanol:

Due to the additive effects of aspirin and ethanol, damage to the gastroduodenal mucosa is increased and bleeding time is prolonged.

【Storage】Seal and store.

[Specifications] 30 pieces/box.

[Validity period] 60 ​​months