Ceritinib

Ceritinib is used to treat non-small cell lung cancer that has spread to other parts of the body. Your doctor will check for an alteration in your genes before starting you on this.

• Take Ceritinib once a day. Take the exact dose that your doctor tells you to.
• Ceritinib should be taken after food unless otherwise instructed by your doctor
• Do not break open or crush the capsules. Swallow the capsule whole.
  • Inform your doctor or pharmacist if you have difficulty swallowing

If you forget to take a dose, take it as soon as you remember. However, if there are less than 12 hours to your next dose, skip the missed dose and take your next dose at the usual time. Do not take two doses at the same time.

Inform your healthcare professional if:

• You are allergic to this medication or any of the other ingredients of this medication
• You or your partner becomes pregnant or is planning for pregnancy. You should use effective birth control during and for at least:
  • Three months after stopping treatment (for men)
  • Six months after stopping treatment (for women)
• You are breastfeeding
  • Do not breastfeed during and for at least two weeks after stopping treatment
• You are taking any other medications, including supplements, traditional medications and herbal remedies
• You have any other medical conditions (e.g.diabetes, heart problems)

Maintain personal hygiene and take precautions against infection.

• Nausea or vomiting, decreased appetite
  • Take small, frequent meals throughout the day
• Diarrhea or constipation
  • To manage diarrhea:
    • Drink plenty of clear fluids to replace those lost (two litres everyday)
    • Avoid oily or spicy food and milk or dairy products
  • To manage constipation:
    • Drink more water or clear fluids (unless you have a limit on the amount that you can take each day)
    • Add more fibre to your diet by eating more fruits and vegetables
• Stomach discomfort
• Feeling tired and lack of energy
  • Do not drive or operate machinery when you feel tired
• Increased blood sugar level

• Symptoms of a drug allergy including one or more of the following:
  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body
• Sudden onset of cough, chest pain, shortness of breath, with fever
• Dark urine or light coloured stools
• Yellowing of your eyes or skin
• Very bad stomach pain, nausea, vomiting or diarrhea
• Feeling very thirsty and having to pass urine very often
• Slow or abnormal heartbeat
• Unusual weakness, tiredness or lightheadedness

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

Avoid taking grapefruit or grapefruit juice when you are taking this medication as it may interact with your medication and increase the risk of side-effects.

Store in a cool and dry place, away from direct sunlight. Keep this medication away from children.